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The effect of HFS at the different aromatase blockade times. A, Time courses of the effects of HFS delivered 2.5 min (gray circles) or 5 min (black circles) after letrozole. B, The frequency of LTP (black columns), LTD (white columns), and no effect (NE, gray columns) induced by HFS in the presence of DMSO and at 2.5, 5, and 30 min after letrozole was administered (p < 0.0002 and 0.00001, χ2 test).
