Figure 4.
The effect of a combined blockade of GABAARs and aromatase or ERs on HFS-LTP. A, B, Time courses of the effects of HFS applied in the presence of bicuculline alone (gray circles) or bicuculline + letrozole (black circles) (A) and in the presence of bicuculline alone (gray circles) or bicuculline + ICI (black circles) (B). C, The frequency of LTP (black columns), LTD (white columns), and no effect (NE, gray columns) induced by HFS in the presence of bicuculline (BIC), bicuculline + letrozole (BIC+LE), and bicuculline + ICI (BIC+ICI). D, E, Mean ± SD of N1 amplitude (percentage) (D) and mean ± SD of N1 potentiation rise time (in minutes) (E) after HFS under the different drugs. *p < 0.05, Student's t test.