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. 2009 Sep 16;29(37):11582–11593. doi: 10.1523/JNEUROSCI.5712-08.2009

Figure 3.

Figure 3.

Stat3-CPOMC mice show increased food intake and defects in compensatory refeeding resulting from decreased POMC expression. A, Daily food intake of control (white bar), Stat3-CPOMC (black bar), and Stat3-C/CPOMC (gray bar) mice at the age of 10 weeks (n = 8–18/genotype). B, Compensatory 4 and 24 h refeeding after a 24 h fasting period of control (white bars), Stat3-CPOMC (black bars), and Stat3-C/CPOMC (gray bars) mice at the age of 16 weeks (n = 7–9/genotype). C, Relative hypothalamic expression of POMC, AgRP, and NPY under random-fed conditions of control (white bars), Stat3-CPOMC (black bars), and Stat3-C/CPOMC (gray bars) mice by use of quantitative real-time PCR (n = 8/genotype). D, X-gal stainings of brains isolated from ROSAArte26POMC and Stat3-CPOMCROSAArte26 mice at 12 weeks of age. Displayed values are means ± SEM. *p ≤ 0.05 versus control.