Table 1.
A brief summary of Creb and/or Crem knock-out mice
| Knock-out | CREB/ATF family expressed in brain | Conditional expression | Viability | Major phenotypes in the nervous system | References |
|---|---|---|---|---|---|
| Creb1αΔ | CREBβ, CREM | Viable to adulthood | No gross abnormality of development; deficient long-term memory |
Hummler et al., 1994 Bourtchuladze et al., 1994 Blendy et al., 1996b |
|
| Creb1−/− | CREM | Perinatal death | Enlarged ventricles; reduced commissures | Rudolph et al., 1998 | |
| Crem−/− | CREB | Viable to adulthood | Circadian rhythm abnormalities; lower anxiety levels |
Nantel et al., 1996 Blendy et al., 1996a Maldonado et al., 1999 |
|
| CrebNescre Crem−/− | Developmental (E16.5 and onward) in neuronal and glial progenitors | Perinatal death | Progressive neurodegeneration in all areas of the brain | Mantamadiotis et al., 2002 Aguado et al., 2009 | |
| CrebCamkcre4 Crem−/− | Postnatal in forebrain regions | Viable to adulthood | Progressive neurodegeneration in hippocampus and striatum | Mantamadiotis et al., 2002 |