Figure 6.

Behavioral responses to dopaminergic agonists are altered in dopamine-depleted NCAM^−/− mice. A combination of reserpine (5 mg/kg, i.p.) and methyl-dl-tyrosine (250 mg/kg, i.p.) was applied to deplete dopamine in NCAM^+/+ and NCAM^−/− mice. After injection of the dopamine receptor agonist apomorphine (1 mg/kg, s.c.), dopamine-depleted NCAM^+/+ and NCAM^−/− mice were placed into the open field, and locomotor activity was immediately monitored for 30 min at 5 min intervals. Time course of the effect of apomorphine on the locomotor activity of dopamine-depleted NCAM^+/+ and NCAM^−/− mice is shown. Distance moved was counted at 5 min intervals. Mean + SEM values are shown (n = 5).