Figure 2.

Sensitivity of medullary slice preparations to local application of ATP in the rVRG/preBötC emerges near E17. A, E17 preparations exhibited slow, irregular bursting behavior in 7 mm K⁺. Integrated XII nerve root recordings from two E17 rhythmic medullary slices showing that, in one slice, brief bouts of rhythmic activity could be evoked only by local application of SP (1 μm, 10 s) into the rVRG/preBötC (B), whereas in another slice, both ATP (0.1 mm, 10 s) and SP evoked brief rhythmic activity (C).