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Blocking effects of the selective CB1 antagonist, SR141716, on SAB-378-indcued analgesia during noxious CRD in rats. Data represent the overall response to CRD (AUC of distensions 7–12) in animals pretreated with either vehicle or SR141716 (300 nmol/kg) and receiving thereafter either vehicle or SAB-378 (2.7 μmol/kg). Data are mean ± SEM of 4–5 animals per group. *p < 0.05 vs other experimental groups.
