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Effects of WIN55,212-2 on the pressure–volume relationship during CRD in rats. Vehicle (1 ml/kg × 2) or WIN55,212-2 (100 nmol/kg, a single dose or two doses) was administered intravenously immediately before starting the CRD procedure (single dose) and after the 5fh distension (repeated treatment), as indicated by the arrows. Data are mean ± SEM of eight animals per group.
