Figure 4.
Correlation between the in vivo PET data and the motor behavioral performance. The animals were tested on spontaneous motor behaviors using the cylinder test (a), amphetamine (c), and apomorphine (e) induced rotations. The use of the affected paw (left side) in the cylinder test was severely impaired after lesion. This impairment was maintained in rAAV5–GFP-injected animals, whereas the treatment group showed a significant recovery of function (a). The improvement in the cylinder test, expressed as difference between the pre-vector and post-vector injection time points, was highly correlated with the KdVr values derived from the striatal PET data (b). The correlations between drug-induced rotation and KdVr values were weaker (d, f. Statistics in a: two-way ANOVA, χ2(5,44) = 31.68, p < 0.001; c, two-way ANOVA, χ2(3,29) = 23.65, p < 0.001; e, two-way ANOVA, χ2(3,29) = 35.60, p < 0.001. All two-way analysis was followed by individual contrasts with Bonferroni's correction. Regression line fits in b, d, and f are two-tailed significance of the Pearson's product-moment correlation coefficient. * indicates different from pre-transduction score; † indicates different from lesion/GFP.