Figure 1.

Increased anxiety behavior in PLC-β4^−/− mice in open-field, elevated plus-maze, and light/dark transition tests. A, Locomotor activity in the open field. B, Number of central crosses in the open field. C, Time in the central sector of the open field. D, Thigmotaxis index: the lower the index, the higher the thigmotaxis (see Materials and Methods for detail). E, Percentage entries into the open arms of the elevated plus-maze. F, Total number of entries in the elevated plus-maze. G, Light/dark transition number. H, Total time in the light compartment. *p < 0.05, **p < 0.01, two-tailed t test; all data are presented as means ± SEM from 10 mice per genotypes.