Medial septum-selective PLC-β4 knockdown replicates the theta rhythm heterogeneity phenotype of PLC-β4−/− mice. A, Representative EEG waveforms during walking for wild-type mice injected with lentiviruses expressing control shRNA (control shRNA mice) and wild-type mice injected with lentivirus encoding shPLC-β4 (shPLC-β4 mice). B, Averaged power spectra of the EEG waveforms recorded during walking for control shRNA mice (n = 7) and shPLC-β4 mice (n = 7). C, Representative EEG waveforms during urethane anesthesia for control shRNA mice and shPLC-β4 mice. D, Averaged power spectra of the EEG waveforms recorded during urethane anesthesia for control shRNA mice (n = 7) and shPLC-β4 mice (n = 7). *p < 0.05, two-tailed t test; all data are presented as means ± SEM.