Figure 6.

Rivastigmine rescues impaired cholinergic theta rhythms in PLC-β4^−/− mice. A, Representative EEG waveforms during walking for wild-type mice with intraperitoneal injection of saline (WT-sham), PLC-β4^−/− mice with intraperitoneal injection of saline (KO-sham), and PLC-β4^−/− mice with intraperitoneal injection of rivastigmine (KO-rivastigmine). B, Averaged power spectra of the EEG waveforms recorded during walking for WT-sham (n = 10), KO-sham (n = 10), and KO-rivastigmine (n = 10). C, Representative EEG waveforms during alert immobility for WT-sham (black trace), KO-sham (blue trace), and KO-rivastigmine (red trace). D, Averaged power spectra of the EEG waveforms recorded during alert immobility for WT-sham (n = 10), KO-sham (n = 10), and KO-rivastigmine (n = 10). All data are presented as means ± SEM.