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. 2009 Dec 9;29(49):15445–15454. doi: 10.1523/JNEUROSCI.4195-09.2009

Figure 2.

Figure 2.

Phenotype investigation of Schwann cell PrP knock-out in transverse sciatic nerve sections. a, b, Detection of Cre-mediated β-galactosidase expression via X-Gal histochemistry (blue) counterstained with nuclear fast red in Cre control ROSA26-positive mice (b) but not ROSA26 mice lacking Cre (a). Images taken at ×20 magnification. c, d, Detection of PrPC expression (red) via immunofluorescence in myelin structures of Cre control mice (c) but not Schwann cell PrP knock-out mice (d). Scale bars, 20 μm. e, f, Normal myelin morphology observed in both floxed PrP control mice (e) and Schwann cell PrP knock-out transgenic mice (f). Scale bars, 5 μm.