Figure 6.
a–p, Immunocytochemical detection of PrPSc deposition in terminal tissue sections from Schwann cell PrP KO mice (a, c, e, g, i, k, m, o) and normal PrP-expressing control mice (b, d, f, h, j, l, n, p) following oral (a–l) or intraperitoneal (m–p) 139A or ME7 challenge. Tissue sections: brain (hippocampus), longitudinal spinal cord showing deposition in gray matter tracts, and spleen showing deposition in germinal centers. Following peripheral infection, the PrPSc deposition pattern in Schwann cell PrP knock-out animals was again indistinguishable from control genotype mice in all tissues investigated.