Figure 7.
a–l, Immunocytochemical detection of PrPSc deposition in preclinical tissues following oral challenge (a, c, e, g, i, k); serial sections screened without anti-PrP antibody (−ab) are shown for comparison (b, d, f, h, j, l). At 126 d after 139A oral challenge, PrPSc deposition was detected in the brain in the red nucleus (arrow in a), surrounding but not inside magnocellular neurons (c). PrPSc deposition was detected only within Peyer's patches of ileal tissue (e, g). Investigation of the celiac–superior mesenteric ganglion (CSMG) complex revealed PrPSc deposition in associated lymph nodes (i, k).