Figure 8.

a–f, Pathological vacuolar change was assessed following transmission of mouse-adapted scrapie strains 139A (a, c, e) and ME7 (b, d, f) via intracerebral (a, b), intraperitoneal (c, d), and oral (e, f) routes. Brains were scored on a scale of 0–5 in nine gray matter areas and 0–3 in three white matter areas, animals were grouped following postmortem confirmation of genotype, and were mean scores calculated (error bars representing ±SEM). Brain scoring areas: 1, dorsal medulla; 2, cerebellar cortex; 3, superior colliculus; 4, hypothalamus; 5, medial thalamus; 6, hippocampus; 7, septum; 8, cerebral cortex; 9, forebrain cerebral cortex; 10, cerebellar white matter; 11, midbrain white matter; 12, cerebral peduncle. Legend: ♦, Schwann cell PrP knock-out; ■, floxed PrP control; ▲, Cre control; ●, nontransgenic control.