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. 2009 Sep 30;29(39):12244–12254. doi: 10.1523/JNEUROSCI.1970-09.2009

Figure 7.

Figure 7.

Effects of intra-amygdala injection of β-adrenoceptor antagonists propranolol on actin rearrangements in the DH and CPA behaviors induced by conditioned naloxone-precipitated morphine withdrawal. A, Schematic representation of injection sites in the amygdala of rats used to determine the effect of intra-amygdala injection of propranolol on morphine withdrawal-induced CPA behaviors (○, control; •, propranolol). B, Intra-amygdala injection of propranolol prevents actin rearrangements in the DH induced by conditioned morphine withdrawal in acute morphine-dependent rats. Propranolol (15 nmol/0.5 μl per side) or vehicle (0.5 μl/side) was bilaterally microinjected into the amygdala 10 min before naloxone-precipitated morphine withdrawal. Values are expressed as the mean ± SEM. **p < 0.01, compared with the corresponding vehicle-microinjected control group, one-way ANOVA with Bonferroni's post hoc test. Nal, Naloxone; CMW, conditioned morphine withdrawal.