Theta synchronization in Gad65−/− mice during generalized fear. Average values for the second positive peak for cross-correlations between the LA and CA1 (A), CA1 and PFC (B), and LA and PFC (C), recorded during the CS−. Gad65+/+ mice did not freeze during the CS−, so all correlations in this genotype represent nonfreezing behavior. In contrast, generalized fear occurred in Gad65−/− mice during R1, E, and RS allowing cross-correlograms for both freezing and nonfreezing periods to be obtained. During R1, freezing-specific correlations between all recording areas in Gad65−/− mice were significantly higher than those obtained for Gad65+/+. All data are expressed as mean ± SEM. Numbers within each bar indicates the number of observations. *p < 0.05, **p < 0.01.