Figure 2.
GABAA receptor-dependent disinhibition induces cardiovascular responses that reflect static, but not dynamic, allodynia. The time course of changes in arterial blood pressure responses (ΔMAP) evoked by dynamic (light brushing) or static (6.0 g von Frey hair) mechanical stimuli applied on the face of anesthetized rats immediately after microinfusion of bicuculline within the MDH is shown. Graphs represent the mean response (±SEM) of rats (n = 4/group) to 10 s long stimuli. Bicuculline significantly and reversibly increased blood pressure in response to face stimulation with a 6 g von Frey for 25 min after application.