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. 2009 Feb 25;29(8):2519–2527. doi: 10.1523/JNEUROSCI.3923-08.2009

Figure 4.

Figure 4.

Unlike capsaicin, light, dynamic mechanical stimuli applied under glycine disinhibition do not produce NK1 receptor internalization in dorsal horn neurons. A, Image of NK1 receptor-expressing neurons in the MDH as revealed by immunofluorescence. B, Numerical image illustrating a lamina I MDH neuron internalizing NK1 receptors in response to injection of capsaicin in the upper lip. C, Numerical image illustrating a lamina I NK1 immunopositive neuron in the MDH of a rat in which light brushing of the ipsilateral lip was applied after intracisternal strychnine. Scale bars: A, 200 μm; B, C, 10 μm. D, Bar histograms summarizing the percentage of neurons internalizing the NK1 receptor in the different laminae of the MDH after capsaicin injection into the lip. E, Bar histograms summarizing the percentage of neurons internalizing the NK1 receptor in the different laminae of the MDH after brushing of the lip under strychnine. D, E, I–IIo, Laminae I and outer II; IIi–IIIo, laminae inner II and outer III; IIIi–IV, laminae inner III and IV; *p < 0.05, ***p < 0.001.