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Importance of the TM3–TM4 loop for rescue of protein function. A, Traces of glycine-gated (100 μm, 500 μm, and 3 mm) currents of truncated tails (α1–iDΔ19–TM4, α1–iDΔ37–TM4, or α1–iDΔ62–TM4) coexpressed with α1A-trc. B, Bar diagram demonstrating reduction in whole-cell maximal current amplitudes (in picoamperes) of tail variants coexpressed with α1A-trc compared with α1A wt.
