Figure 6.

Effect of treatment with finasteride or clomiphene on expression of the δ and γ₂ subunits of the GABA_A-R during pregnancy. Finasteride (25 mg/kg), clomiphene (5 mg/kg), or vehicle was administered daily from day 12 to day 18 of pregnancy. A–D, Rats were killed at day 19 of pregnancy and the hippocampus was subjected to immunohistochemistry for semiquantitative measurement of δ subunit (A, B) or γ₂ subunit (C, D) immunoreactivity in the dentate gyrus and the CA1 region, respectively. Data are expressed as percentage of change relative to the corresponding value for rats in estrus and are means ± SEM from at least eight animals per group. Results from rats treated with the vehicle for finasteride or with that for clomiphene were pooled. *p < 0.05, **p < 0.01 versus rats in estrus; ^†p < 0.05 versus vehicle-treated rats at day 19 of pregnancy (one-way ANOVA followed by Scheffe's test).