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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: J Magn Reson. 2019 Mar 4;301:102–108. doi: 10.1016/j.jmr.2019.03.003

Fig. 4.

Fig. 4.

Pyruvate and lactate compartmentation based on 13C and 2H distribution in lactate, alanine and glutamate. The 13C isotopomers indicate a complete equilibration in the alanine and lactate pools. However, the 2H isotopomers show that exchange between pyruvate and alanine is rapid, indicated by the thicker arrow. Based on 2H distribution in glutamate, pyruvate exchanging with lactate preferentially supplies the acetyl-CoA pool entering the TCA cycle. The readout metabolites are highlighted.