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. Author manuscript; available in PMC: 2019 Jul 30.
Published in final edited form as: Int J Infect Dis. 2019 Apr 30;84:15–21. doi: 10.1016/j.ijid.2019.04.026

Figure 5.

Figure 5

Monte Carlo simulation of CSF rifampicin target attainment according to rifampicin MIC level, comparing standard (10 mg/kg) and intensified (20 mg/kg) dosing strategies. (a) Rifampicin CSF AUC0–24/MIC ratio of 30, corresponding to a 1-log10 fall in colony-forming units for extracellular Mycobacterium tuberculosis. The dashed line and circles represent the standard weight-based dosing bands, approximating 10 mg/kg. The solid line and squares represent the intensive weight-based dosing bands, approximating 20 mg/kg. (b) Optimal rifampicin CSF AUC0–24/ MIC ratio of 297, corresponding to rifampicin EC50 against extracellular M. tuberculosis. The dashed line and circles represent the standard weight-based dosing bands, approximating 10 mg/kg. The solid line and squares represent the intensive weight-based dosing bands, approximating 20 mg/kg.