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. 2009 Jul 29;29(30):9651–9659. doi: 10.1523/JNEUROSCI.0833-09.2009

Figure 4.

Figure 4.

Neurorestorative effects of MANF. Rats were administered 6-OHDA (20 μg) unilaterally in the striatum. Four weeks later, the rats received a single injection of either vehicle, GDNF (10 μg), or MANF (10 μg). The rotational behavior was measured 1 week before and 2, 4, 6, and 8 weeks after the injection of the growth factors. a, Cumulative amphetamine-induced ipsilateral rotations. Means ± SEM are show; n = 6–10 in each group. b, Combined cumulative amphetamine-induced ipsilateral rotations measured at 3, 6, 8, 10, and 12 weeks after lesion. c, Number of TH-positive cells in the SNpc. Means ± SEM are shown; n = 6–9 in each group. Tukey–Kramer's post hoc analysis after one-way ANOVA, ***p < 0.001, **p < 0.01 versus the corresponding control.