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. 2009 Jul 29;29(30):9458–9470. doi: 10.1523/JNEUROSCI.2047-09.2009

Figure 5.

Figure 5.

RyR-mediated ER Ca2+ stores contribute differently to LTP in NonTg and 3xTg-AD mice. A, Graph shows changes in baseline fEPSP slope from NonTg (black circles; n = 7) and 3xTg-AD (gray squares; n = 5) mice after treatment with 10 μm dantrolene. B, Bar graph shows fEPSP slope of pretetanus (white and light gray, respectively) and posttetanus (black and gray hatched, respectively) baselines in the presence of dantrolene as percentage of predantrolene baseline (black and dark gray, respectively) in NonTg and 3xTg-AD mice. C, Top, Representative pretetanus fEPSP traces before (1) and after (2) treatment with dantrolene and posttetanus fEPSP traces (3) with dantrolene from NonTg (black) and 3xTg-AD (gray) mice. Bottom, Graph shows averaged time course of LTP with predrug baseline, pretetanic, and posttetanic baseline with dantrolene treatment from NonTg (black circles) and 3xTg-AD (gray squares) mice. The black arrow indicates the time of tetanus. * indicates significantly different from 3xTg-AD before dantrolene treatment. Error bars represent ±SEM, p < 0.05, and n denotes the number of slices.