Figure 7.

Blockage of glial glutamate uptake restores inhibition during BS. A, Intracellular recording in the suprasylvian gyrus during topical application of dihydrokainate. Neurons discharged synchronously during the bursting phase of the BS pattern. However, the membrane potential displayed an unusually increased background activity during the isoelectric line (see inset). B, Histograms of membrane potentials of two neurons during 20 s periods of isoelectric activity. The upper histogram corresponds to a neuron recorded under low isoflurane conditions, while the lower histogram reflects the neuron at left. C, Neuronal response to CL thalamic stimulation during BS shows a similar excitatory-inhibitory pattern as during light anesthesia. Averaged responses (n = 15) are shown on the left, whereas individual responses during BS (top) and during low isoflurane conditions (bottom) are displayed on the right.