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. 2009 Aug 5;29(31):9850–9860. doi: 10.1523/JNEUROSCI.5176-08.2009

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Copyright © 2009 Society for Neuroscience 0270-6474/09/299850-11$15.00/0

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Figure 9. — Effect of iontophoretic application of GABA on cortical responsiveness to thalamic stimulation. A1, Averaged (n = 15) evoked membrane potentials during low isoflurane conditions (light 1.5% isoflurane anesthesia), before and after the application of GABA (black traces), and during GABA iontophoresis (red traces). Note the diminished amplitude of both excitatory and inhibitory components. A2, Similar sequence of procedures in the same neuron recorded during BS. The application of GABA resulted in diminished excitatory responses, whereas inhibitory components were completely absent. B, Effect of GABA application on membrane input resistance during low isoflurane conditions (1) and during BS (2). In both cases GABA reduced the input resistance of the neuron.