Table 4. ITS analysis comparing health check and control participants.
Figures are adjusted mean differences (95% CI, P value) except where indicated.
| Mean difference between cases and controls | Mean change per year for cases and controls | Year following the health check | ||||||
|---|---|---|---|---|---|---|---|---|
| 1st year | 2nd year | 3rd year | 4th year | 5th year | 6th year | |||
| BMI, mean, Kg/m2 | −0.27 | 0.08 | −0.29 | −0.35 | −0.41 | −0.05 | −0.18 | −0.30 |
| (-0.31 to -0.23, <0.001) | (0.07 to 0.09, <0.001) | (-0.31 to -0.27, <0.001) | (-0.37 to -0.33, <0.001) | (-0.45 to -0.37, <0.001) | (-0.11 to 0.01, 0.07) | (-0.26 to -0.10, <0.001) | (-0.39 to -0.20, <0.001) | |
| Current smoking, OR | 0.70 | 0.97 | 0.97 | 0.93 | 0.91 | 0.91 | 0.92 | 0.90 |
| (0.69 to 0.71, <0.001) | (0.96 to 0.97, <0.001) | (0.96 to 0.98, <0.001) | (0.92 to 0.94, <0.001) | (0.89 to 0.93, <0.001) | (0.89 to 0.93, <0.001) | (0.90 to 0.94, <0.001) | (0.87 to 0.94, <0.001) | |
| SBP, mean, mm Hg | −1.21 | 0.18 | −1.58 | −1.69 | −1.90 | −0.72 | −0.96 | −1.43 |
| (−1.29 to −1.13, <0.001) | (0.16 to 0.20, <0.001) | (−1.64 to −1.52, <0.001) | (−1.77 to −1.61, <0.001) | (−1.99 to −1.80, <0.001) | (−0.86 to −0.58, <0.001) | (−1.16 to −0.76, <0.001) | (−1.70 to −1.16, <0.001) | |
| DBP, mean, mm Hg | −0.45 | −0.04 | −0.96 | −0.94 | −0.97 | −0.62 | −0.72 | −0.93 |
| (−0.51 to −0.39, <0.001) | (−0.05 to −0.03, <0.001) | (−0.99 to −0.92, <0.001) | (−0.99 to −0.88, <0.001) | (−1.03 to −0.91, <0.001) | (−0.72 to −0.52, <0.001) | (−0.84 to −0.60, <0.001) | (−1.11 to −0.75, <0.001) | |
| TC, mean, mmol/L | 0.01 | −0.02 | −0.04 | −0.05 | −0.08 | −0.05 | −0.05 | −0.05 |
| (0.002 to 0.02, 0.06) | (−0.02 to −0.01, <0.001) | (−0.04 to −0.03, <0.001) | (−0.06 to −0.04, <0.001) | (−0.09 to −0.07, <0.001) | (−0.06 to −0.04, <0.001) | (−0.07 to −0.03, <0.001) | (−0.07 to −0.03, <0.001) | |
| HDL cholesterol, mean, mmol/L | 0.01 | 0.004 | −0.01 | −0.01 | −0.02 | 0.0005 | 0.01 | 0.01 |
| (0.006 to 0.01, <0.001) | (0.003 to 0.005, <0.001) | (−0.01 to −0.008, <0.001) | (−0.01 to −0.008, <0.001) | (−0.02 to −0.01, <0.001) | (−0.003 to 0.004, 0.83) | (0.004 to 0.02, 0.01) | (0.002 to 0.02, 0.21) | |
Abbreviations: BMI, body mass index; CI, confidence interval; DBP, diastolic blood pressure; HDL, high-density lipoprotein; OR, odds ratio; SBP, systolic blood pressure, TC, total cholesterol.
Differences were estimated as case controls using generalised estimation equation models, adjusting for each variable shown as well as age, sex, and deprivation fifth.