| Assessment criteria by study design |
| Q1. Study design and sampling method is appropriate to the study question |
| Q2. Adequate sample size (>100), or sample size calculations undertaken |
| Q3. Response rate reported and acceptable (>70%) |
| Q4. Disability/impairment measure is clearly defined and reliable |
| Q5. Depression and/or anxiety measure is clearly defined and reliable |
| Q6. Potential confounders are taken into account in analysis |
| Q7. Confidence intervals are presented |
| Case control (additional criteria) |
| Q8. Cases and controls are comparable |
| Q9. Cases and controls are clearly defined |
| Cohort (additional criteria) |
| Q10. Groups being studied are comparable at baseline |
| Q11. Losses to follow up are presented and acceptable |
