Table 2. Univariate and multivariate analyses of predictors of CSS in the study population after propensity score matching (PSM).
| Risk Factors | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | HR (95% CI) | P Value | HR | HR (95% CI) | P Value | |
| Age | ||||||
| <50 | (-) | (-) | ||||
| ≥50 | 1.11 | 0.64–1.95 | 0.706 | 1.29 | 0.70–2.36 | 0.419 |
| Gender | ||||||
| Female | (-) | (-) | ||||
| Male | 0.93 | 0.60–1.44 | 0.740 | 1.43 | 0.84–2.43 | 0.192 |
| Race | ||||||
| White | (-) | (-) | ||||
| Black | 1.72 | 0.99–3.01 | 0.056 | 1.39 | 0.76–2.54 | 0.286 |
| Other | 1.61 | 0.84–3.08 | 0.153 | 1.14 | 0.52–2.51 | 0.743 |
| Marital status | ||||||
| Married | (-) | (-) | ||||
| Single | 1.17 | 0.60–2.29 | 0.642 | 1.02 | 0.49–2.11 | 0.953 |
| Divorce | 1.35 | 0.85–2.16 | 0.209 | 1.05 | 0.62–1.79 | 0.850 |
| Histology | ||||||
| Adenocarcinoma | (-) | (-) | ||||
| Mucinous | 1.24 | 0.73–2.13 | 0.426 | 1.51 | 0.84–2.74 | 0.172 |
| SRCC | 2.00 | 0.73–5.51 | 0.180 | 1.37 | 0.41–4.62 | 0.608 |
| Grade | ||||||
| Well | (-) | (-) | ||||
| Moderate | 1.34 | 0.66–2.74 | 0.422 | 1.08 | 0.51–2.27 | 0.845 |
| Poor | 2.26 | 1.06–4.78 | 0.034 | 1.25 | 0.54–2.91 | 0.597 |
| No. of positive LNs | ||||||
| 0 | (-) | (-) | ||||
| 1–3 | 2.87 | 1.74–4.75 | 0.000 | 3.18 | 1.78–5.68 | 0.000 |
| ≥4 | 5.50 | 3.13–9.67 | 0.000 | 5.62 | 2.86–11.05 | 0.000 |
| Size (cm) | ||||||
| ≤2 | (-) | (-) | ||||
| 2–5 | 0.84 | 0.46–1.54 | 0.563 | 0.67 | 0.35–1.26 | 0.213 |
| >5 | 1.19 | 0.66–2.14 | 0.569 | 0.79 | 0.41–1.52 | 0.483 |
| Radiotherapy | ||||||
| Yes | (-) | (-) | ||||
| No | 1.20 | 0.72–1.98 | 0.488 | 1.71 | 0.73–4.00 | 0.213 |
| Chemotherapy | ||||||
| Yes | (-) | (-) | ||||
| No | 1.00 | 0.62–1.61 | 0.998 | 0.58 | 0.24–1.40 | 0.228 |
| Primary Tumor | ||||||
| RA | (-) | (-) | ||||
| AA | 1.96 | 1.25–3.07 | 0.003 | 2.06 | 1.29–3.27 | 0.002 |
SRCC: Signet Ring Cell Carcinoma; No: Number; LN: Lymph Node; RA: Rectal Adenocarcinoma; AA: Anal Adenocarcinoma