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. 2019 Jul 30;14(7):e0219937. doi: 10.1371/journal.pone.0219937

Table 3. Univariate analysis of predictors of CSS in patients with AA.

Risk Factors N(%) Univariate analysis
HR HR (95% CI) P Value
Age
<50 26(19.12) (-)
≥50 110(80.88) 1.27 0.62–2.60 0.522
Gender
Female 51(37.5) (-)
Male 85(62.5) 1.07 0.61–1.88 0.807
Race
White 102(75) (-)
Black 20(14.71) 1.47 0.71–3.04 0.299
Other 14(10.29) 0.83 0.29–2.33 0.720
Marital status
Married 74(54.41) (-)
Single 22(16.18) 0.97 0.42–2.23 0.947
Divorce 40(29.41) 0.86 0.46–1.59 0.619
Histology
Adenocarcinoma 108(79.41) (-)
Mucinous 24(17.65) 1.08 0.52–2.23 0.838
SRCC 4(2.94) 1.07 0.26–4.44 0.925
Grade
Well 18(13.24) (-)
Moderate 83(61.03) 1.19 0.46–3.09 0.720
Poor 35(25.74) 2.18 0.81–5.90 0.123
No. of positive LN
0 22(16.18) (-)
1–3 61(44.85) 2.93 1.55–5.53 0.001
≥4 53(38.97) 4.24 2.08–8.62 0.000
Size (CM)
≤2 85(62.5) (-)
2–5 32(23.53) 0.62 0.29–1.32 0.211
>5 19(13.97) 1.01 0.49–2.07 0.985
Radiotherapy
Yes 42(30.88) (-)
No 94(69.12) 1.61 0.84–3.08 0.150
Chemotherapy
Yes 43(31.62) (-)
No 93(68.38) 1.30 0.71–2.39 0.390

SRCC: Signet Ring Cell Carcinoma; No: Number; LN: Lymph Node; RA: Rectal Adenocarcinoma; AA: Anal Adenocarcinoma