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. Author manuscript; available in PMC: 2019 Jul 30.
Published in final edited form as: Neuroscience. 2018 Jul 27;388:224–238. doi: 10.1016/j.neuroscience.2018.07.028

Table 1.

Candidate proteins regulated via local translation in the PAP by pyridazine analogs

Mass Spectrometry RNA Array
Primary Function Accession Description 4 h Fold 24 h Fold Z-score
Antioxidant Response Q8K4Z3 NAD(P)H-hydrate epimerase 2.93 11.42 2.002
CO2 Regulation P00920 Carbonic anhydrase 2 2.12 3.13 2.471
Cell Adhesion Q6P9K9 Neurexin-3 6.57 8.09 2.250
E9QNF7 Contactin-associated protein-like 2 2.57 4.79 2.184
G3XA53 Oligodendrocyte myelin glycoprotein 1.98 3.37 2.311
G3UZM4 Cell adhesion molecule 2 3.86 3.30 2.910
Q53YX2 Thymus cell antigen 1, theta 1.97 3.28 2.224
D6QSS8 A disintegrin and metallopeptidase domain 22 1.60 2.15 2.465
Q6PGJ3 L1 cell adhesion molecule 2.07 1.89 2.249
Cytoskeleton Structure P68369 Tubulin alpha-1A 1.82 1.78 5.833
P20357 Microtubule-associated protein 2 2.23 5.62 2.833
P60710 Actin, cytoplasmic 1 3.79 5.54 4.309
Q9R0P5 Destrin 1.62 5.40 2.159
Q9BW30 Tubulin polymerization-promoting protein family 3 3.30 4.38 2.939
Q9D6F9 Tubulin beta-4A chain 4.76 4.32 2.796
P18760 Cofilin-1 1.70 3.39 3.503
B2RQQ5 Microtubule-associated protein 1B 1.98 2.76 4.451
E9Q1G8 Septin-7 1.67 2.61 2.758
P68368 Tubulin alpha-4A chain 2.10 2.44 4.786
Q3TGE1 Actin-related protein 3 2.44 2.30 2.904
P99024 Tubulin beta-5 chain 2.64 2.07 2.105
Q7TMM9 Tubulin beta-2A chain 1.98 1.81 3.816
Endocytosis/Exocytosis Q3UHD6 Sorting nexin-27 5.00 13.99 2.195
F7BQW7 Synaptojanin-1 3.39 8.73 2.524
P18572 Basigin 5.50 8.14 2.404
Q80TZ3 Putative tyrosine-protein phosphatase auxilin 2.28 4.82 2.540
Q9JIS5 Synaptic vesicle glycoprotein 2A 2.29 3.70 3.657
P46096 Synaptotagmin-1 2.73 3.17 4.007
Q3UHJ0 AP2-associated protein kinase 1 2.01 3.06 2.195
Q9ES97 Reticulon-3 1.69 2.95 3.543
O08599 Syntaxin-binding protein 1 1.97 2.72 3.824
O54734 Dolichyl-diphosphooligosaccharide–protein glycosyltransferase 48 kDa subunit 1.54 2.13 2.306
O55100 Synaptogyrin-1 19.83 13.87 2.614
Q8R191 Synaptogyrin-3 2.02 5.06 2.339
P17426 AP-2 complex subunit alpha-1 1.80 2.53 2.116
Q9WV55 Vesicle-associated membrane protein-associated protein A 1.63 1.51 2.716
Q3TXX4 Vesicular glutamate transporter 1 2.06 11.18 4.170
Endoplasmic Reticulum
 Transporter		 Q5DTI2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.66 2.43 5.158
Energy Metabolism Q9CQJ8 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 3.69 4.24 3.224
Q3UIQ2 NADH dehydrogenase (ubiquinone) Fe-S protein 1 2.47 2.93 2.303
P56391 Cytochrome c oxidase subunit 6B1 1.89 2.56 3.370
Q91VA7 Isocitrate dehydrogenase [NAD] subunit 2.20 2.55 2.175
Q3TIC8 Ubiquinol-cytochrome c reductase core protein 1 3.72 1.91 2.486
Q9DB77 Cytochrome b-c1 complex subunit 2, mitochondrial 1.71 1.83 2.596
Fatty Acid Metabolism Q8BLF1 Neutral cholesterol ester hydrolase 1 4.28 11.32 2.062
P19096 Fatty acid synthase 2.74 3.19 2.122
P60202 Myelin proteolipid protein 4.17 2.20 5.029
Q99L43 Phosphatidate cytidylyltransferase 2 1.80 1.68 4.955
Glutamate Homeostasis P05202 Aspartate aminotransferase, mitochondrial 5.25 5.75 2.289
P15105 Glutamine synthetase 2.38 4.94 3.381
P05201 Aspartate aminotransferase, cytoplasmic 1.75 3.46 3.073
Q8BH59 Calcium-binding mitochondrial carrier protein Aralar1 2.39 1.70 2.046
Glycolysis P47857 ATP-dependent 6-phosphofructokinase, muscle type 3.16 5.19 2.995
P09411 Phosphoglycerate kinase 1 1.83 2.58 3.403
P05063 Fructose-bisphosphate aldolase C 1.77 1.97 2.794
P35486 Pyruvate dehydrogenase E1 component subunit alpha, somatic 2.11 1.57 2.388
Glycosylation Q9DBE8 Alpha-1,3/1,6-mannosyltransferase ALG2 2.96 5.06 2.140
GPCR Signaling B2RSH2 Guanine nucleotide-binding protein G(i) subunit a1 4.15 5.77 2.673
Q66L47 Guanine nucleotide binding protein, alpha stimulating, olfactory type 4.38 5.54 2.023
O54865 Guanylate cyclase soluble subunit beta-1 3.38 5.03 3.359
Hormone Production Q543R4 Carboxypeptidase E 1.90 2.48 5.434
Ion Channel F7AMU5 Sodium channel, voltage-gated, type II, alpha 1.73 3.09 3.546
Q9Z1L5 Voltage-dependent calcium channel subunit alpha-2/delta-3 1.84 1.98 2.580
P63141 Potassium voltage-gated channel subfamily A2 3.35 1.87 2.529
J3QMG3 Voltage-dependent anion-selective channel protein 3 4.77 9.45 3.629
Ion Channel Regulator E9QN98 Inactive dipeptidyl peptidase 10 1.79 4.27 3.301
E9PWX1 Dipeptidyl aminopeptidase-like protein 6 1.90 3.04 2.249
Kinase/Phosphatase P84309 Adenylate cyclase type 5 3.68 2.13 2.726
 Signaling B2RX66 Serine/threonine-protein kinase TAO1 7.18 17.27 2.169
Q9CQR6 Serine/threonine-protein phosphatase 6 catalytic 7.38 11.79 2.378
P52480 Pyruvate kinase 2.70 8.04 3.448
Q9JLM8 Doublecortin like kinase 1 1.70 7.35 3.603
P63328 Serine/threonine-protein phosphatase 1.86 5.71 3.938
Q543F6 Cyclin-dependent kinase 5 3.42 5.52 2.138
Q3TYK4 Protein kinase, cAMP dependent regulatory, type Ia 1.56 3.84 3.167
Q60737 Casein kinase II subunit alpha 2.83 3.19 2.023
Q76MZ3 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1.76 3.15 3.732
P63318 Protein kinase C gamma 1.95 2.95 2.994
E9QAQ5 Glycogen synthase kinase-3 beta 1.55 2.49 2.565
Q01065 Calcium/calmodulin-dependent 3’,5’-cyclic nucleotide phosphodiesterase 1B 1.61 2.48 2.152
Q924S8 Sprouty-related, EVH1 domain-containing protein 1 1.59 2.38 2.195
P68404 Protein kinase C beta 1.78 2.35 3.530
P16054 Protein kinase C epsilon 1.86 2.35 2.084
P28652 Calcium/calmodulin-dependent protein kinase type IIb 1.63 2.28 2.481
E9Q3L2 Phosphatidylinositol 4-kinase alpha 1.78 1.62 3.160
Mitochondrial Transporter Q91VR2 ATP synthase subunit gamma 1.68 3.57 2.145
P48962 ADP/ATP translocase 1 1.66 3.01 3.286
Plasma Membrane B2BH30 Metabotropic glutamate receptor 5 2.87 6.63 2.275
 Receptor A2AI21 Glutamate receptor ionotropic, NMDA 1 2.28 5.45 2.326
Q03137 Ephrin type-A receptor 4 2.95 5.30 2.723
Q9QYS2 Metabotropic glutamate receptor 3 4.59 5.04 2.886
O55022 Membrane-associated progesterone receptor component 1 3.27 4.61 3.220
P12023 Amyloid beta A4 precursor protein 3.31 2.94 4.095
P62812 Gamma-aminobutyric acid receptor subunit alpha-1 3.36 2.84 3.530
P22723 Gamma-aminobutyric acid receptor subunit gamma-2 2.55 2.45 2.218
B1AXV0 DOMON domain-containing protein FRRS1L 1.53 2.26 3.493
P15209 BDNF/NT-3 growth factors receptor 3.62 2.19 3.006
Q8C419 G-protein-coupled receptor 158 1.73 2.03 3.192
C9K0Y3 AMPA-selective glutamate receptor 1 flip type 1.85 1.72 2.582
Plasma Membrane G3X9J1 Sodium/calcium exchanger 1 4.96 9.71 2.908
 Transporter Q3UYK6 Excitatory amino acid transporter 2 2.19 4.60 4.288
P31648 Sodium- and chloride-dependent GABA transporter 1 2.79 2.98 3.463
P48066 Sodium- and chloride-dependent GABA transporter 3 2.20 4.97 2.666
Q3UR55 Sodium/potassium-transporting ATPase subunit beta 2.11 2.88 2.188
G5E829 Plasma membrane calcium-transporting ATPase 1, PMCA1 1.58 2.52 3.485
F8WHB1 Calcium-transporting ATPase, PMCA2 1.75 2.31 2.550
A2ALL9 Calcium-transporting ATPase, PMCA3 1.90 2.28 2.155
Q3UHK1 Proton myo-inositol cotransporter 1.67 2.09 2.582
E9Q828 Calcium-transporting ATPase, PMCA4 1.75 1.92 2.708
Protein Folding/Chaperone Q542X7 Chaperonin containing Tcp1, subunit 2 (beta) 1.84 5.79 2.481
P38647 Stress-70 protein, mitochondrial 3.52 5.24 2.345
P11499 Heat shock protein HSP 90-beta 2.04 4.23 4.474
P63017 Heat shock cognate 71 kDa protein 2.92 4.00 3.325
Q61699 Heat shock protein 105 kDa 5.51 3.92 2.494
Q571M2 Heat shock protein 4 4.45 3.67 2.230
P17742 Peptidyl-prolyl cis–trans isomerase A 1.69 1.94 4.528
P14211 Calreticulin 2.12 1.70 2.193
Protein Turnover P10605 Cathepsin B 2.78 5.29 4.259
Q9QZM0 Ubiquilin-2 2.44 4.35 2.216
Q6ZQ38 Cullin-associated NEDD8-dissociated protein 1 3.94 2.90 2.035
Q01853 Transitional endoplasmic reticulum ATPase 1.91 2.66 2.655
Q7TQI3 Ubiquitin thioesterase OTUB1 2.02 2.50 2.294
Q3U900 Dolichyl-diphosphooligosaccharide–protein glycosyltransferase subunit 1 1.64 2.30 2.758
RNA Binding Protein Q3U1S6 Cold shock domain-containing protein E1 1.61 2.64 2.545
Scaffolding Q91XM9 Post-synaptic density protein 93 2.45 3.06 2.444
Q8C8R3 Ankyrin-2 2.07 2.87 3.297
O54991 Contactin-associated protein 1 1.63 1.50 3.241
Signal Transduction P19157 Glutathione S-transferase P 1 4.23 7.04 2.771
Q9Z1B3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 4.31 6.08 2.042
Q3TIQ3 Phosphatidylinositol transfer protein alpha isoform 2.53 6.05 2.005
Q3UKW2 Calmodulin 2.46 5.91 4.572
Q8BVQ5 Protein phosphatase methylesterase 1 4.54 4.61 2.224
Q6R891 Neurabin-2 2.36 4.43 2.513
Q5SS40 14–3-3 protein epsilon 3.33 3.95 3.784
Q6AXD2 Abl-interactor 2 2.61 3.24 2.505
P63101 14–3-3 protein zeta/delta 2.08 2.95 3.085
Q811P8 Rho GTPase-activating protein 32 1.80 2.63 2.709
Q9CQV8 14–3-3 protein beta/alpha 1.72 2.04 2.298
Trafficking Q68FF6 ARF GTPase-activating protein GIT1 6.92 11.52 2.182
P62823 Ras-related protein Rab-3C 3.28 5.25 2.817
Q3TJ43 Vacuolar protein sorting 35 4.26 4.36 2.690
Q3UPA3 GDP dissociation inhibitor 2 2.80 3.93 3.089
P51150 Ras-related protein Rab-7a 2.15 3.60 2.078
Q3TD71 Secretory carrier membrane protein 1 3.49 3.35 3.142
P46460 Vesicle-fusing ATPase 1.96 3.14 3.320
Q9JHU4 Cytoplasmic dynein 1 heavy chain 1 1.73 2.48 3.818
P39053 Dynamin-1 1.95 2.38 3.035
Q6PHU5 Sortilin 2.87 1.89 3.191
Q9D4I9 RAB23 1.54 1.61 2.709
P61164 Alpha-centractin 2.63 2.66 2.528
Translation O55091 Protein IMPACT 1.60 8.67 3.437
P62274 40S ribosomal protein S29 2.63 3.25 3.500
Vacuolar Proton Pump Q3TG21 ATPase, H+ transporting, lysosomal V1 subunit A 1.67 6.85 3.087
P50516 ATPase, H+ transporting, lysosomal V1 subunit A 3.16 5.24 3.666
Q8BVE3 ATPase, H+ transporting, lysosomal V1 subunit H 1.98 3.23 2.134
P51863 ATPase, H+ transporting, lysosomal V0 subunit D1 2.20 3.14 3.221
Q9Z1G4 ATPase, H+ transporting, lysosomal V0 subunit A1 1.96 3.13 3.893