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. 2019 Jul 30;14(7):e0220569. doi: 10.1371/journal.pone.0220569

Fig 4. MNS1 compounds induce apoptosis and inhibit migration in adult GBM cells.

Fig 4

(a) Flow cytometry analysis of annexin V/PI staining in dBT114 cells showed dose dependent decrease of cell viability, via apoptosis with treatment of MNS1-Leu for 24h. Values are the means ± S.E.M (error bars) of triplicate experiments. (b) Western blot analysis showed decreased expression of Bcl-2 with increased dose of MNS1-MV or MNS1-Leu. Total Erk1/2 was used as loading control. Images of (c) dBT116 (aHGG) migration assay and (d) quantification after MNS1-MV treatment. Images of (e) dBT116 migration assay and (f) quantification post MNS1-Leu treatment. Values are the means ± S.E.M (error bars) of triplicate experiments. 8 fields were imaged at 20X and counted in each experimental group.