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. Author manuscript; available in PMC: 2020 Sep 5.
Published in final edited form as: Eur J Pharmacol. 2019 Jun 22;858:172485. doi: 10.1016/j.ejphar.2019.172485

Fig. 4.

Fig. 4.

RA inhibits CaMKII autophosphorylation through Crabp1. (A) GL261 glioma cells, where Crabp1 is not expressed, were transfected with Flag-Crabp1 or empty vector and pre-treated with RA (0.1 μM) for 30 min prior to Ca2+ stimulation for 15 min. (B) Differentiated C2C12 cells were pre-treated with RA for the indicated time prior to 2 μM ionomycin stimulation for 15 min. Statistical analyses are shown in the middle. *P < 0.05 vs. control vehicle and **P < 0.05 vs. ionomycin only (n=3, student t-test). Lower panels show the control, RA alone has negligible effect on CaMKII.