Table 2.
White matter microstructure and cortical anatomy as mediators of the association between PRS for ADHD and symptoms of hyperactivity-impulsivity. Results are for the White non-Hispanic subpopulation (N = 352 for white matter microstructure; N= 301 for anatomic); similar results held when adding the African American subpopulation. Empirical p values for each cluster were determined by permutation.
| White matter microstructure | |||||
|---|---|---|---|---|---|
| Location | PRS threshold | MNI coordinates (x,y,z) | Cluster size (mm3) | β (CI) | p-value |
| Right anterior corona radiata | 0.1 | (18.5, 19.2, 31.5) | 104 | −0.031 (−0.061 to −0.0078) | < 0.004** |
| 0.2 | (18.5, 18.4, 32.2) | 112 | −0.033 (−0.064 to −0.0093) | < 0.004** | |
| 0.3 | (18.5, 18.4, 32.2) | 112 | −0.034 (−0.065 to −0.01) | < 0.004** | |
| 0.4 | (18.5, 18.4, 32.2) | 112 | −0.032 (−0.063 to −0.0093) | < 0.004** | |
| 0.5 | (18.5, 19.4, 32.3) | 88 | −0.025 (−0.052 to −0.0052) | 0.01** | |
| Right superior corona radiata | 0.1 | (27.5, −15.2, 25.2) | 64 | −0.022 (−0.049 to −0.0033) | 0.02** |
| 0.2 | (27.5, −12.3, 25.3) | 104 | −0.027 (−0.054 to −0.0065) | 0.004** | |
| 0.3 | (27.5, −13.6, 25.4) | 80 | −0.027 (−0.055 to −0.0063) | 0.01** | |
| 0.4 | (27.5, −13.9, 25.4) | 96 | −0.026 (−0.053 to −0.0058) | 0.008** | |
| 0.5 | (27.5, −15, 25.8) | 88 | −0.032 (−0.062 to −0.0082) | 0.01** | |
| Right anterior corona radiata and anterior thalamic radiation | 0.3 | (24.3, 20.6, 25.4) | 80 | −0.026 (−0.054 to −0.0048) | 0.01** |
| 0.4 | (24.7, 20.8, 25.2) | 80 | −0.025 (−0.054 to −0.0039) | 0.01** | |
| Cortical anatomy | ||||||
|---|---|---|---|---|---|---|
| Location | PRS threshold | MNI coordinates (x,y,z) | Cluster size (mm2) | β (CI) | p-value | |
| Left dorsomedial prefrontal cortical thickness | 0.1 | (−8, 40, 21) | 162.05 | −0.026 (−0.057 to −0.0039) | 0.04** | |
| 0.2 | (−5, 36, 33) | 367.09 | −0.029 (−0.061 to −0.0047) | 0.02** | ||
| 0.3 | (−6, 38, 26) | 175.07 | −0.024 (−0.054 to −0.002) | 0.06 | ||
| 0.4 | (−5, 33, 34) | 308.97 | −0.028 (−0.059 to −0.0048) | 0.01** | ||
| 0.5 | (−5, 27, 39) | 227.22 | −0.028 (−0.06 to −0.0056) | 0.03** | ||
| Right lateral temporal cortical surface area | 0.1 | (65, −30, −28) | 304.92 | 0.023 (0.002 to 0.052) | 0.04** | |
| 0.2 | (65, −30, −28) | 447.62 | 0.024 (0.0034 to 0.054) | 0.03** | ||
| 0.3 | (65, −29, −27) | 391.8 | 0.024 (0.003 to 0.054) | 0.02** | ||
| 0.4 | (66, −27, −27) | 207.12 | 0.022 (0.0022 to 0.052) | 0.09 | ||
**
FDR corrected, q < .05