Table 1.
Novel significant drivers found in at least two tissue types
| Gene | #Missense | #LoF | #Silent | log10BF | Tumor | Function |
|---|---|---|---|---|---|---|
| C3orf70 | 14/3 | 1/1 | 0/0 | 9.3/3.8 | BLCA/CESC | Unknown |
| COL11A1 | 7/13 | 4/2 | 0/0 | 2.2/2.2 | KIRC/PRAD | Collagen formation, expression associated with colorectal, ovarian cancers, etc. (23934190, 11375892) |
| CUL3 | 15/8/4 | 5/4/0 | 1/0/0 | 3.5/3.8/2.6 | HNSC/KIRP/ PRAD | Core component of E3 ubiquitin ligase complex, with many downstream targets affecting carcinogenesis, like NRF2 (24142871) |
| LZTR1 | 9/10 | 0/1 | 0/2 | 2.9/2.1 | GBM/UCEC | Adaptor of CUL3-containing E3 ligase complexes. Inactivation drives glioma self renewal and growth (23917401) |
| MAPK1 | 9/7 | 0/1 | 0/0 | 15.1/ 12.8 | CESC/HNSC | MAP kinase. The MAPK/ERK cascade has well characterized and important roles in cancer (17496922) |
| MGA | 35/11 | 16/5 | 5/3 | 3.8/2.7 | LUAD/UCEC | Dual-specificity transcription factor, can inhibit MYC-dependent cell transformation (10601024) |
| SOS1 | 12/7 | 1/0 | 3/0 | 3.5/7.0 | LUAD/UCEC | Guanine nucleotide exchange factor for RAS proteins, which are well-known for roles in cell proliferation (17486115) |
| ZBTB7B | 11/5 | 1/1 | 0/0 | 6.2/2.3 | BLCA/UCS | Transcriptional regulator of lineage commitment of immature T-cell precursors (17878336) |
| ZFP36L1 | 12/11 | 4/3 | 1/0 | 3.4/5.2 | BLCA/LUAD | Involved in mRNA degradation. Deletion leads to T lymphoblastic leukemia (20622884) |
| ZNF750 | 17/13 | 3/7 | 2/1 | 3.4/5.1 | BLCA/HNSC | An essential regulator of epidermal differentiation. Depletion promotes cell proliferation in ESCA (24686850) |
We use “/” to separate data obtained from different tumor types as indicated in the “Tumor” column. A brief description of the gene’s function and its known role in cancer is provided in the “Function” column. Reference PMIDs are given in parentheses