Table 1.
Newly identified aGPCR transcript variants.
| aGPCR | Old name | # annotated splice variants in NCBI | # of 5′ start exons (# of already annotated in NCBI) | # of 3′ end exons (# of already annotated in NCBI) | # of exons (# of already annotated in NCBI) | # of all variants (# of variants ≥1% abundance) | # of all exons in identified variants (# of all exon in variants ≥1% abundance) | Average # of all exons in individual variants with ≥1% abundance (min.-max. range) |
|---|---|---|---|---|---|---|---|---|
| ADGRL1 | Lphn1 | 14 | 22 (6) | 19 (1) | 91 (24) | 118 (56) | 132 (83) | 14.5 (2–25) |
| ADGRL2 | Lphn2 | 51 | 29 (4) | 24 (6) | 51 (35) | 108 (37) | 104 (57) | 15.5 (2–22) |
| ADGRL3 | Lphn3 | 36 | 28 (3) | 29 (7) | 42 (36) | 69 (9) | 99 (37) | 17.2 (2–26) |
| ADGRL4 | Eltd1 | 1 | 16 (1) | 13 (1) | 22 (14) | 59 (3) | 51 (16) | 15.4 (15–16) |
| ADGRE1 | Emr1 | 4 | 19 (1) | 9 (2) | 39 (22) | 52 (9) | 67 (31) | 17.2 (3–22) |
| ADGRE4 | Emr4 | 1 | 16 (1) | 11 (1) | 31 (17) | 41 (4) | 58 (24) | 14.3 (8–17) |
| ADGRE5 | Cd97 | 7 | 16 (1) | 13 (1) | 48 (20) | 117 (19) | 77 (31) | 17.3 (2–21) |
| ADGRA2 | Gpr124 | 5 | 16 (2) | 16 (3) | 41 (19) | 74 (29) | 73 (49) | 12.8 (3–20) |
| ADGRA3 | Gpr125 | 1 | 17 (1) | 16 (1) | 31 (18) | 66 (6) | 64 (22) | 13.2 (2–19) |
| ADGRC1 | Celsr1 | 5 | 16 (2) | 8 (1) | 46 (34) | 26 (9) | 70 (49) | 22.9 (4–35) |
| ADGRC2 | Celsr2 | 5 | 23 (2) | 15 (1) | 56 (33) | 49 (22) | 94 (65) | 20.8 (3–34) |
| ADGRD1 | Gpr133 | 3 | 9 (2) | 10 (1) | 32 (26) | 33 (7) | 51 (31) | 21.0 (10–26) |
| ADGRF5 | Gpr116 | 8 | 23 (2) | 13 (1) | 43 (29) | 105 (19) | 79 (32) | 20.8 (15–22) |
| ADGRB3 | Bai3 | 4 | 18 (3) | 6 (1) | 39 (33) | 41 (11) | 63 (39) | 18.6 (3–31) |
| ADGRG1 | Gpr56 | 19 | 19 (10) | 9 (2) | 23 (15) | 67 (9) | 51 (21) | 13.7 (5–14) |
| ADGRG2 | Gpr64 | 22 | 17 (3) | 10 (1) | 35 (30) | 56 (32) | 62 (45) | 21.8 (3–29) |
| ADGRG3 | Gpr97 | 5 | 11 (3) | 12 (1) | 22 (14) | 52 (24) | 45 (36) | 7.9 (3–12) |
| ADGRG6 | Gpr126 | 7 | 12 (3) | 6 (2) | 32 (24) | 29 (22) | 50 (42) | 16.4 (2–26) |
All aGPCRs which were expressed with FPKM ≥0.5 at least in one of the three tissues were analyzed in respect to transcript variants. Following the catalog of Halvardson et al.115 newly identified exons are counted. # annotated 5′ start exons: identical splice donor; # annotated 3′ end exons: identical splice acceptor; # annotated exons: defined by a donor site and an acceptor site. A detailed analysis of the variant number and exon composition is given in suppl. Table S4.