Table 2.
Putative receptor variants derived from mouse aGPCR transcripts.
| aGPCR | Old symbol | NTF domain variability | soluble NTF | membrane anchored NTF | CTF (or CTF with domain-less N terminus) | variability in 7TM | variability in C terminus |
|---|---|---|---|---|---|---|---|
| ADGRL1 | Lphn1 | X | X | X | X | X | |
| ADGRL2 | Lphn2 | X | X | X | |||
| ADGRL3 | Lphn3 | X | X | X | |||
| ADGRL4 | Eltd1 | X | |||||
| ADGRE1 | Emr1 | X | X | X | |||
| ADGRE4 | Emr4 | X | X | X | |||
| ADGRE5 | Cd97 | X | X | X | |||
| ADGRA2 | Gpr124 | X | X | X | X | ||
| ADGRA3 | Gpr125 | X | |||||
| ADGRC1 | Celsr1 | X | X | X | X | ||
| ADGRC2 | Celsr2 | X | X | X | |||
| ADGRD1 | Gpr133 | X | X | X | |||
| ADGRF5 | Gpr116 | X | X | X | |||
| ADGRB3 | Bai3 | X | X | X | |||
| ADGRG1 | Gpr56 | X | |||||
| ADGRG2 | Gpr64 | X | X | X | |||
| ADGRG3 | Gpr97 | X | X | ||||
| ADGRG6 | Gpr126 | X | X | X | |||
| of all aGPCRs | 72.2% | 55.6% | 22.2% | 66.7% | 11.1% | 55.6% | |
Based on the ORFs of the abundant aGPCR transcript variants the resulting proteins are categorized. 7TM, seven-transmembrane domain; CTF, C-terminal fragment; NTF, N-terminal fragment.