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. 2019 Jul 30;9:11055. doi: 10.1038/s41598-019-47444-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional characterizations of the derived microglia-like cells. (A) mRNA gene expression of (i) TNF-α, IL-6, and (ii) MMP2, MMP3 after Aβ42 oligomer stimulation for 72 hours (n = 3). *Indicates p < 0.05 for the different test conditions. (B) Quantification of micron-sized particles of iron oxide (MPIO) phagocytosis by microglia-like cells and iPSC-NPC (neural progenitor cells) and iPSC-EC (endothelial cells) controls (called as iNPC and iEC). Black line: negative control; red line: cells with MPIO. (C) The cytokine secretion of microglia-like cells (n = 3), stimulated by Aβ42 oligomers (0.5 µM), Lipopolysaccharides (LPS) (100 ng/ml), and dexamethasone (1 µM) for 72 hours as determined by ELISA assays. (i) PGE2; (ii) TGF-β1 and (iii) VEGF-A. *Indicates p < 0.05 for the test conditions compared to the control.