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. 2019 Jun 8;26:18–29. doi: 10.1016/j.molmet.2019.06.001

Figure 5.

Figure 5

CF-RELN alters pre- and post-synaptic inputs onto ARH-POMC-EGFP neurons. A, Representative traces from a voltage-clamp experiment showing both reduced and enhanced mIPSC frequency after bath application of CF-RELN (100 nM) in POMC-EGFP neurons. B, Normalized mIPSC frequency (n = 14) before and after treatment of CF-RELN (0.9 ± 0.1-fold; Bold line, cumulative mean change; one-way ANOVA with pairwise analysis) C, Fold change of mIPSC frequency in CF-RELN reduced (0.8 ± 0.1-fold; left) and enhanced (1.1 ± 0.04-fold; right) as determined by KS-test. D, Baseline mIPSC frequency of neurons which CF-RELN reduced (R; n = 5) or enhanced (E; n = 9) mIPSC frequency E, Mean amplitude of mIPSCs before and after CF-RELN application (n = 14). Between-cell analysis performed using a paired t-test or mixed-effects model with Tukey's post-hoc analysis. (Error bars indicate ± SEM *p < 0.05).