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. 2019 Jul 24;10:812. doi: 10.3389/fphar.2019.00812

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Copyright © 2019 Chen, Leong, Leung, Chan, Li, Qiu, Ko and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of XEASD treatment on glutamate and aspartate levels in brain tissue of IDPN-induced TS mice. (A) Biochemical assay of glutamate levels was performed as described in Materials and Methods. (B) Levels of aspartate in brain tissues were measured as described in Materials and Methods. Control 1 represents normal control mice; control 2 represents IDPN-challenged control mice. Data are expressed as the percentage of non-challenged control 1 values. *P < 0.05, significantly different from the control 1; ^# P < 0.05, significantly different from the IDPN control 2. The value of the glutamate levels of control 1 (mean ± S.E.M.) and aspartate level of control 1 (mean ± S.E.M.) were 2953 ± 440 (nmol/mg protein) and 0.73 ± 0.06 (nmol/mg protein), respectively.