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. 2019 Jul 24;10:499. doi: 10.3389/fendo.2019.00499

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Copyright © 2019 Zhou, Li, Xiao, Ruan, Chu, Ye, Zhong, Zhang, Huang, Xie, Li and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ERβ activation accelerates wound healing in diabetic rats. The experimental rats were divided into 5 groups: control (CTL), diabetic (STZ) treatment, STZ rats treated by 450 μg/kg/day of DPN (STZ/DPN), STZ rats treated by 10 mg/kg/day of MnTBAP (STZ/MnTBAP), or CTL rats treated by 450 μg/kg/day of PHTPP (CTL/PHTPP), for further analysis. (A) Photographs of representative wounds on day 12 after burns. (B) Graphical depiction of wound area in different days after burns. (C) H&E stains of wound tissue on day 12 after burns with occurrence of granulation tissue in the wounds. (D) Numbers of CD31 positive vessels per HPF area on day 12 after burns. (E) The representative pictures for the evaluation of vascularity (assessed by CD31 immunohistochemistry) on day 12 after burns. N = 7. *P < 0.05, vs. CTL group. Data are expressed as mean ± SEM.