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. 2019 Jul 24;10:1688. doi: 10.3389/fmicb.2019.01688

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Copyright © 2019 Woodburn, Jaynes and Clemens.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RP557 immediately destroys P. aeruginosa and S. aureus in an increasing dose-dependent manner. The bactericidal effectiveness of RP557, tobramycin and vancomycin were evaluated against bioluminescent P. aeruginosa 19660 (A) and S. aureus 49525 (B) through 60 min of exposure. The concentration dependence of RP557, tobramycin and vancomycin following 30 min of exposure with P. aeruginosa and S. aureus is shown in (C,D), respectively. The bioluminescence of viable cells was quantitated non-invasively with an IVIS Lumina bioimaging system. Bioluminescence reflects bacterial viability as is directly correlated with number of colony forming units. Data represent the mean ± SE of triplicate replicates from two independent experiments; statistically significant (^*P < 0.05; ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001), using one-way ANOVA followed by Tukey analysis. For some points, the error bars are shorter than the height of the symbols.