Table 1.

Minimum Inhibitory Concentration (MIC, μM, [μg/mL]) evaluation of RP557, LL-37, tobramycin and vancomycin against planktonic gram-positive and gram-negative bacteria and fungi.

Bacteria	RP557	Tachyplesin-1	LL-37	Tobramycin	Vancomycin
Gram-negative isolates
A. baumannii 6043	4.0 [8]	7.1 [16]	14.2 [64]	68.5 [32]	>88.3 [128]
A. baumannii 6838	4.0 [8]	14.1 [32]	>28.5 [128]	4.3 [2]	>88.3 [128]
A. baumannii ATCC 17978	8.0 [16]	3.5 [8]	28.5 [128]	4.3 [2]	>88.3 [128]
E. cloacae 6053	4.0 [8]	3.5 [8]	>28.5 [128]	68.5 [32]	>88.3 [128]
E. cloacae 6054	4.0 [8]	1.8 [4]	>28.5 [128]	137 [64]	>88.3 [128]
K. pneumonia 6066	4.0 [8]	28.2 [64]	>28.5 [128]	8.6 [4]	>88.3 [128]
K. pneumonia 6069	2.0 [4]	7.1 [16]	>28.5 [128]	4.3 [2]	>88.3 [128]
K. pneumonia ATCC 10031	4.0 [8]	3.5 [8]	>28.5 [128]	4.3 [2]	>88.3 [128]
P. aeruginosa 6186	2.0 [4]	3.5 [8]	>28.5 [128]	>274 [128]	>88.3 [128]
P. aeruginosa ATCC 19660	2.0 [4]	3.5 [8]	28.5 [128]	>274 [128]	>88.3 [128]
P. aeruginosa ATCC 27853	2.0 [4]	1.8 [4]	28.5 [128]	4.3 [2]	>88.3 [128]
Gram-positive isolates
S. aureus B-767	2.0 [4]	7.1 [16]	>28.5 [128]	>274 [128]	>88.3 [128]
S. aureus 6061	4.0 [8]	3.5 [8]	>28.5 [128]	8.6 [4]	2.1 [3]
MRSA 6313	2.0 [4]	3.5 [8]	>28.5 [128]	>274 [128]	1.4 [2]
MRSA 6381	2.0 [4]	3.5 [8]	>28.5 [128]	274 [128]	1.4 [2]
MRSA ATCC 33592	2.0 [4]	3.5 [8]	>28.5 [128]	137 [64]	1.4 [2]
S. epidermis ATCC 51625	4.0 [8]	1.8 [4]	>28.5 [128]	4.3 [2]	2.1 [3]
Fungi					Amphotericin b
C. albicans Y-326	8.0 [16]	14.1 [32]			1 [1.08]
C. albicans Y-6359	2.0 [4]	14.1 [32]			1 [1.08]
C. parapsilosis Y-1761	8.0 [16]	28.2 [64]			1 [1.08]
C. parapsilosis Y-1763	1.0 [2]	7.1 [16]			1 [1.08]

MIC is the lowest concentration of test article that shows no growth after a 24-h incubation. Data represent the mean of 3 replicates from 2 independent experiments.