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. 2019 Jul 24;10:682. doi: 10.3389/fgene.2019.00682

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Copyright © 2019 Hoffmann and Spengler

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NuRD regulates activity-dependent transcription and neural circuit assembly and function. In cerebellar granule neurons, NuRD triggers deposition of the histone variant H2A.z (free histone ends shown in red) in exchange of the core histone H2A (free histone ends shown in gray) at neuronal-activity-dependent genes to reset transcription. NuRD-dependent modulation of gene expression changes contributes to synaptic pruning activity during sensitive developmental time periods. Thereby, NuRD fine-tunes cerebellar circuit function and promotes sparse encoding of information. Model adapted from (Yang et al., 2016), license number.4576500853137.