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. 2019 Jul 24;10:682. doi: 10.3389/fgene.2019.00682

Figure 4.

Figure 4

NPC types in the developing mammalian neocortex. (A) Neuroepithelial cells prevail prior to the onset of neurogenesis and are therefore not shown. NPCs are classified according to cell polarity, the presence of ventricular contact, and the location of mitosis. Apical progenitors (APs) comprise apical radial glia (aRG) and apical intermediate progenitors (aIPs). APs undergo mitosis at the ventricular surface in the presence of contact of the basal process with the basal lamina as indicated by red arrows. Subapical progenitors (SAPs) undergo mitosis at an abventricular location in the presence of ventricular contact. Basal progenitors (BPs) include basal radial glia (bRG) and basal intermediate progenitors (bIPs). BPs undergo mitosis at an abventricular location in the absence of ventricular contact. bRG subtypes are shown additionally: proliferative bIP (blue circle) and neurogenic bIP (green circle). (B) Coronal section of the developing neocortex from mice. NPC types frequently found in each of the germinal zones are depicted. Schematic is partially from (Florio and Huttner, 2014), license number 4576520625938.