Table 5.
Adjusted** slopes for associations between log10 transformed values of perfluorooctane acid (PFOA) and perfluorooctane sulfonic acid (PFOS) on the adjusted levels of liver function tests (LFT) along with percent changes** in the untransformed lebvels of LFT for 10% changes in the levels of PFOA and PFOS by stages of glomerular function for nonobese and obese US adults aged >= 20 years. Data from National Health and Nutrition Examination Survey 2003–2014.
| Glomerular function stage | Percent change in LFT for 10% change in PFOA and PFOS | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Non-obese Participants | GF-1 | GF-2 | GF-3A | GF-3B/4 | GF-1 | GF-2 | GF-3A | GF-3B/4 | |
| LFT* | |||||||||
| ALT | Log10(PFOA) | 0.00882 (0.55) | 0.04761 (0.02) | 0.00083 (0.98) | −0.00099 (0.94) | 0.08 | 0.45 | 0.01 | −0.01 |
| Log10(PFOS) | −0.00806 (0.50) | 0.01128 (0.51) | −0.01335 (0.73) | −0.08768 (<0.01) | −0.08 | 0.11 | −0.13 | −0.84 | |
| AST | Log10(PFOA) | 0.01352 (0.31) | 0.02783 (0.05) | 0.00227 (0.95) | 0.05548 (0.03) | 0.13 | 0.27 | 0.02 | 0.53 |
| Log10(PFOS) | −0.01342 (0.12) | 0.00687 (0.58) | −0.01534 (0.63) | −0.00372 (0.84) | −0.13 | 0.07 | −0.15 | −0.04 | |
| APH | Log10(PFOA) | −0.00594 (0.60) | −0.00157 (0.91) | −0.01299 (0.69) | 0.01255 (0.13) | −0.06 | −0.01 | −0.12 | 0.12 |
| Log10(PFOS) | −0.00137 (0.92) | −0.01603 (0.26) | 0.00191 (0.95) | −0.05218 (<0.01) | −0.01 | −0.15 | 0.02 | −0.50 | |
| GGT | Log10(PFOA) | 0.05862 (0.01) | 0.07736 (<0.01) | −0.01617 (0.83) | 0.13030 (<0.01) | 0.56 | 0.74 | −0.15 | 1.25 |
| Log10(PFOS) | 0.00819 (0.63) | 0.02213 (0.25) | −0.03163 (0.61) | 0.01293 (0.40) | 0.08 | 0.21 | −0.30 | 0.12 | |
| Obese Participants | |||||||||
| LFT* | |||||||||
| ALT | Log10(PFOA) | 0.07691 (<0.01) | 0.03498 (0.18) | 0.05678 (0.11) | 0.16354 (<0.01) | 0.74 | 0.33 | 0.54 | 1.57 |
| Log10(PFOS) | 0.04840 (<0.01) | 0.00521 (0.79) | 0.03828 (0.09) | 0.06956 (<0.01) | 0.46 | 0.05 | 0.37 | 0.67 | |
| AST | Log10(PFOA) | 0.03872 (<0.01) | 0.02908 (0.12) | 0.03616 (0.03) | 0.04963 (<0.01) | 0.37 | 0.28 | 0.35 | 0.47 |
| Log10(PFOS) | 0.01085 (0.41) | −0.01302 (0.46) | 0.04050 (0.01) | 0.02278 (0.16) | 0.10 | −0.12 | 0.39 | 0.22 | |
| APH | Log10(PFOA) | −0.01720 (0.29) | 0.02195 (0.18) | 0.01718 (0.40) | 0.03871 (0.17) | −0.16 | 0.21 | 0.16 | 0.37 |
| Log10(PFOS) | −0.01230 (0.34) | 0.01548 (0.37) | −0.01131 (0.56) | −0.02362 (0.01) | −0.12 | 0.15 | −0.11 | −0.23 | |
| GGT | Log10(PFOA) | 0.09099 (<0.01) | 0.00947 (0.74) | 0.06276 (0.20) | 0.12278 (0.01) | 0.87 | 0.09 | 0.60 | 1.18 |
| Log10(PFOS) | 0.00340 (0.90) | −0.05827 (0.05) | 0.06186 (0.01) | 0.05180 (0.06) | 0.03 | −0.56 | 0.59 | 0.49 | |
*ALT = alanine aminotransferase, AST = aspartate aminotransferase, APH = alkaline phosphate, GGT = γ-glutamyl transferase.
**Statistically significant slopes and changes are shown in bold letters.