Table 6.
Adjusted** slopes for associations between presence of diabetes and hypertension on the adjusted levels of liver function tests (LFT) along with percent changes** in the untransformed levels of LFT by stages of glomerular function for nonobese and obese US adults aged >= 20 years. Data from National Health and Nutrition Examination Survey 2003–2014.
| Glomerular function stage | Percent change in LFT | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Non-obese Participants | GF-1 | GF-2 | GF-3A | GF-3B/4 | GF-1 | GF-2 | GF-3A | GF-3B/4 | |
| LFT* | |||||||||
| ALT | Diabetes | 0.00638 (0.74) | 0.01165 (0.43) | 0.02855 (0.31) | 0.09177 (<0.01) | 1.5 | 2.7 | 6.8 | 23.5 |
| Hypertension | 0.02829 (<0.01) | 0.04783 (<0.01) | −0.00170 (0.94) | 0.00026 (0.97) | 6.7 | 11.6 | −0.4 | 0.1 | |
| AST | Diabetes | −0.01462 (0.36) | −0.01617 (0.15) | 0.01247 (0.6) | 0.06801 (<0.01) | −3.4 | −3.8 | 2.9 | 17.0 |
| Hypertension | 0.02623 (0.02) | 0.02744 (<0.01) | −0.00354 (0.86) | 0.02390 (<0.01) | 6.2 | 6.5 | −0.8 | 5.7 | |
| APH | Diabetes | 0.02726 (0.04) | −0.01059 (0.47) | 0.00815 (0.79) | −0.00398 (0.08) | 6.5 | −2.5 | 1.9 | −0.9 |
| Hypertension | 0.02619 (<0.01) | 0.01776 (0.01) | 0.02050 (0.27) | 0.04841 (<0.01) | 6.2 | 4.2 | 4.8 | 11.8 | |
| GGT | Diabetes | 0.03186 (0.34) | 0.00664 (0.76) | 0.06194 (0.3) | 0.10672 (<0.01) | 7.6 | 1.5 | 15.3 | 27.9 |
| Hypertension | 0.08877 (<0.01) | 0.04425 (<0.01) | −0.04226 (0.36) | 0.12720 (<0.01) | 22.7 | 10.7 | −10.2 | 34.0 | |
| Obese Participants | |||||||||
| LFT* | |||||||||
| ALT | Diabetes | 0.05512 (<0.01) | 0.02938 (0.16) | 0.00587 (0.73) | 0.09730 (<0.01) | 13.5 | 7.0 | 1.4 | 25.1 |
| Hypertension | 0.03950 (<0.01) | 0.04050 (<0.01) | 0.01430 (0.39) | 0.02272 (0.01) | 9.5 | 9.8 | 3.3 | 5.4 | |
| AST | Diabetes | 0.01958 (0.12) | 0.02855 (0.12) | 0.03227 (<0.01) | 0.04150 (0.01) | 4.6 | 6.8 | 7.7 | 10.0 |
| Hypertension | 0.01721 (0.02) | 0.02011 (0.09) | −0.00566 (0.61) | 0.01132 (0.18) | 4.0 | 4.7 | −1.3 | 2.6 | |
| APH | Diabetes | 0.01829 (0.07) | −0.01227 (0.29) | −0.04446 (<0.01) | −0.01165 (0.36) | 4.3 | −2.9 | −10.8 | −2.7 |
| Hypertension | 0.01291 (0.08) | 0.02600 (0.01) | −0.00697 (0.5) | 0.03617 (0.03) | 3.0 | 6.2 | −1.6 | 8.7 | |
| GGT | Diabetes | 0.08945 (<0.01) | 0.09871 (<0.01) | 0.05154 (0.02) | 0.02082 (0.49) | 22.9 | 25.5 | 12.6 | 4.9 |
| Hypertension | 0.06770 (<0.01) | 0.03989 (0.07) | −0.03176 (0.06) | 0.11660 (<0.01) | 16.9 | 9.6 | −7.6 | 30.8 | |
*ALT = alanine aminotransferase, AST = aspartate aminotransferase, APH = alkaline phosphate, GGT = γ-glutamyl transferase
**Statistically significant slopes and changes are shown in bold letters.