Table 7.
Adjusted regression coefficients with associated p-values for associations between various independent variables and liver function tests by stages of glomerular function for nonobese and obese US adults aged >= 20 years. Data from National Health and Nutrition Examination Survey 2003–2014.
| Glomerular function stage | |||||
|---|---|---|---|---|---|
| Non-obese Participants | GF-1 | GF-2 | GF-3A | GF-3B/4 | |
| LFT* | |||||
| ALT | Age | 0.00117 (<0.01) | −0.00134 (<0.01) | −0.00326 (<0.01) | −0.00461 (<0.01) |
| Log10(BMI) | 0.55278 (<0.01) | 0.36422 (<0.01) | 0.41779 (0.04) | 0.01121 (0.82) | |
| Fasting time | 0.00100 (0.14) | 0.00003 (0.97) | 0.00061 (0.75) | −0.00058 (0.27) | |
| Survey Year | −0.00673 (0.04) | 0.00213 (0.45) | −0.00234 (0.7) | 0.00772 (<0.01) | |
| Alcohol Consumption | 0.00041 (<0.01) | 0.00072 (<0.01) | 0.00067 (0.01) | −0.00081 (<0.01) | |
| AST | Age | 0.00123 (<0.01) | 0.00001 (0.98) | −0.00124 (0.17) | −0.00002 (0.94) |
| Log10(BMI) | −0.04300 (0.36) | −0.09346 (0.13) | −0.07432 (0.68) | −0.38093 (<0.01) | |
| Fasting time | −0.00022 (0.69) | −0.00081 (0.25) | 0.00035 (0.85) | 0.00108 (<0.01) | |
| Survey Year | −0.00093 (0.71) | 0.00355 (0.08) | 0.00348 (0.57) | 0.01379 (<0.01) | |
| Alcohol Consumption | 0.00045 (<0.01) | 0.00081 (<0.01) | 0.00012 (0.51) | 0.00049 (0.05) | |
| APH | Age | 0.00132 (<0.01) | 0.00164 (<0.01) | 0.00082 (0.38) | −0.00457 (0.01) |
| Log10(BMI) | 0.18248 (<0.01) | 0.14377 (0.03) | 0.33088 (0.06) | −0.45189 (<0.01) | |
| Fasting time | −0.00043 (0.45) | −0.00108 (0.07) | −0.00192 (0.28) | 0.00097 (0.27) | |
| Survey Year | −0.00708 (<0.01) | −0.00591 (0.01) | −0.01199 (0.04) | −0.00281 (0.48) | |
| Alcohol Consumption | −0.00005 (0.5) | −0.00017 (0.24) | 0.00060 (<0.01) | −0.00187 (<0.01) | |
| GGT | Age | 0.00357 (<0.01) | 0.00159 (<0.01) | 0.00017 (0.93) | −0.00545 (0.16) |
| Log10(BMI) | 0.53167 (<0.01) | 0.45019 (<0.01) | 0.55649 (0.12) | −0.65744 (<0.01) | |
| Fasting time | 0.00151 (0.16) | −0.00009 (0.94) | 0.00210 (0.57) | −0.00550 (0.01) | |
| Survey Year | 0.00192 (0.68) | 0.00265 (0.51) | −0.02288 (0.04) | 0.00652 (0.17) | |
| Alcohol Consumption | 0.00104 (<0.01) | 0.00173 (<0.01) | 0.00107 (<0.01) | −0.00036 (0.61) | |
| Obese Participants | |||||
| ALT | Age | −0.00203 (<0.01) | −0.00356 (<0.01) | −0.00256 (<0.01) | −0.00652 (<0.01) |
| Log10(BMI) | 0.16916 (0.08) | 0.20850 (0.12) | 0.55588 (<0.01) | 0.40211 (<0.01) | |
| Fasting time | 0.00012 (0.89) | 0.00177 (0.34) | −0.00256 (<0.01) | −0.00109 (0.59) | |
| Survey Year | −0.00001 (1) | −0.00259 (0.56) | −0.00028 (0.95) | −0.00996 (0.21) | |
| Alcohol Consumption | 0.00064 (<0.01) | 0.00090 (0.13) | 0.00020 (0.04) | −0.00195 (<0.01) | |
| AST | Age | −0.00000 (0.99) | −0.00047 (0.23) | 0.00136 (0.05) | −0.00141 (<0.01) |
| Log10(BMI) | 0.04516 (0.45) | 0.07471 (0.44) | 0.39621 (<0.01) | −0.07178 (0.03) | |
| Fasting time | −0.00071 (0.22) | 0.00051 (0.78) | −0.00143 (0.03) | −0.00448 (<0.01) | |
| Survey Year | −0.00124 (0.66) | 0.00328 (0.39) | −0.00503 (0.01) | −0.00394 (0.57) | |
| Alcohol Consumption | 0.00058 (<0.01) | 0.00106 (0.14) | 0.00048 (<0.01) | −0.00150 (<0.01) | |
| APH | Age | 0.00100 (<0.01) | 0.00013 (0.7) | −0.00057 (0.32) | −0.00370 (<0.01) |
| Log10(BMI) | 0.18161 (<0.01) | 0.27315 (0.01) | 0.11483 (0.16) | 0.38603 (<0.01) | |
| Fasting time | 0.00049 (0.28) | −0.00183 (0.03) | −0.00055 (0.61) | 0.00144 (0.33) | |
| Survey Year | −0.00688 (0.01) | −0.00692 (0.02) | −0.01344 (<0.01) | −0.01782 (<0.01) | |
| Alcohol Consumption | 0.00020 (0.23) | −0.00009 (0.44) | 0.00050 (<0.01) | −0.00023 (0.56) | |
| GGT | Age | 0.00134 (0.02) | −0.00095 (0.2) | 0.00470 (<0.01) | −0.01172 (<0.01) |
| Log10(BMI) | 0.17025 (0.13) | 0.44200 (0.03) | 1.08678 (<0.01) | 0.77029 (<0.01) | |
| Fasting time | 0.00080 (0.45) | 0.00264 (0.34) | 0.00178 (0.21) | −0.00787 (<0.01) | |
| Survey Year | −0.00266 (0.5) | −0.01094 (0.11) | −0.00032 (0.97) | −0.01861 (0.06) | |
| Alcohol Consumption | 0.00141 (<0.01) | 0.00193 (0.05) | 0.00325 (<0.01) | 0.00113 (0.13) | |
*ALT = alanine aminotransferase, AST = aspartate aminotransferase, APH = alkaline phosphate, GGT = γ-glutamyl transferase
**Statistically significant slopes are shown in bold letters.